Avance Medical

Novel autologous, high concentrated fibrin as advanced hemostatic agent for coronary surgery

Slobodan Micovic a, *, Peter Everts b , Branko Calija a , Evgenija Strugarevic a , Nikola Grubor c , Mladen Boricic a , Jelena Lesanovic a , Henk Box d , Dzihan Abazovic e

Abstract

Background: Variability in transfusion outcomes and excessive postoperative bleeding represents a significant problem in cardiac surgery. The effort to reduce bleeding complications and transfusion outcomes is desirable. Our study investigated the feasibility of reducing bleeding complications and transfusion requirements by applying perioperatively prepared autologous bio-regenerative fibrin sealant. Methods: A prospective, case-control study enrolled 74 patients undergoing coronary artery bypass grafting by a single surgeon. Patients in the control group (N = 43), received traditional methods of hemostasis, while patients in the experimental group (N = 31) were treated additionally with autologous bio-regenerative fibrin. Results: Patients were well-matched with regard to basic demographic, laboratory and procedural data. Allogeneic blood transfusion requirement in control group was 39.5 % (17 of 43 patients), compared to 6.5 % (2 of 31 patients) in treated group (p < 0,001). The lower infection rate in the experimental group was also noted. No safety issues were identified during the preparation and application process. Conclusion: Autologous bio-regenerative fibrin can be safely prepared, with no time consuming, and was demonstrated to be a useful tool to decrease allogeneic blood transfusion requirements following elective coronary artery bypass grafting surgery. A prospective randomized trial is needed to confirm these findings. 
https://www.sciencedirect.com/science/article/abs/pii/S1473050221001373

Cell therapy in Osteoarthritis

Avance presented at 1^st Workshop On musculosceletal regenerative medicine : From basic science to clinical practice, 2019, Jakarta, Indonesia;

“Regenerative medicine: Spotlight on cell therapies”

“Cell therapy in osteoarthritis”

Spotlight on cell therapies at AAOS

Avance presented at American Academy of Orthopaedic Surgeons, 2019, Las Vegas, Nevada, USA;

“Regenerative medicine: Spotlight on cel therapies”

I'm not ready for Metal Avance presented at ICRS

ocus Meeting, ICRS, I’m not ready for metal-2018, Milan, Italy;

“A new horizon in cell-based therapies for cartilage repair”

Avance presents at EFSM

14^th Congress of the European Federation of Societies for Microsurgery 2018, Belgrade; Serbia;

“From basic research to therapy – contemporaryapproaches in stem cells based regenerative treatments“