Society for Advancement of Blood Management accepts abstract for annual meeting

Avance Medical is pleased to announce the acceptance of our abstract at the annual meeting of the Society for the Advancement of Blood Management titled: “Improved post-operative haemostasis with associated reduction of allogeneic blood transfusions following application of intra-operatively prepared autologous bio-regenerative fibrin sealant in elective coronary artery bypass surgery.” held in Orlando in September 2015

http://www.sabm.org/ 

Avance nominated for De Vigier Prize 2015

Avance Medical is pleased to announce being nominated for the 2015 De Vigier prize. Avance was selected as one of the top 10 start-up companies in Switzerland from multiple hundreds of company entries.

http://www.devigier.ch/en-US/Home-en 

Graft occlusions caused by transfusions in heart surgery

Is transfusion associated with graft occlusion after cardiac operations?

Engoren M¹, Schwann TA², Jewell E³, Neill S³, Benedict P³, Likosky DS⁴, Habib RH⁵.

Abstract

BACKGROUND:

Packed red blood cell (RBC) transfusions are associated with increased mortality after coronary artery bypass grafting (CABG) but not after cardiac valve operations. Transfusions are associated with increased strokes and deep venous thromboses after cardiac operations as well as increased peripheral vascular graft thrombosis. The purpose of this study was to determine if RBC transfusions were associated with a greater hazard of an occluded graft developing after CABG.

METHODS:

Patients who underwent symptom-driven coronary artery angiography after CABG were analyzed using Cox models and propensity scoring to compare outcomes based on the RBC transfusion status during their index CABG hospitalization.

RESULTS:

We analyzed 940 patients. We found that patients who received transfusions were more likely to have occluded grafts on angiography (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.03-1.50; p = 0.02). After adjusting for other factors, we found that RBC transfusion was associated with about a 20% increased hazard of graft occlusion (HR, 1.21; 95% CI,1.07-1.37; p = 0.003).

CONCLUSIONS:

Perioperative RBC transfusion is associated with graft occlusion after CABG at both the patient and graft levels. These results add to the growing body of evidence that homologous RBC transfusion is not risk free but is associated with a variety of adverse effects including midterm graft failure.

ESCVS poster accepted

We are very pleased to accounce the acceptance of a study comparing donor blood transfusion rates and volumes with AvanCell(TM) Bio-Regenerative Fibrin System against current standard of care for a poster presentation at the 64th ESCVS, International Congress of the European Society of Cardiovascular and Endovascular Surgery in Istanbul, 26-29 March 2015. http://www.escvs2015.org/

Donor blood transfusions 30% higher mortality - SRF 1 Puls with Prof. D. Spahn

A documentary program on Swiss television, SRF 1 Puls, aired 26 January 2015 discussed the risk factors associated with donor blood transfusions. Prof. Donat Spahn outlined his 'patient blood management' concept whereby all steps are taken to reduce donor blood tranfusions peri-operatively. The program stated a 30% higher mortality recorded with those receiving DBTs vs. those that do not.

http://www.srf.ch/player/tv/puls/video/puls-vom-26-01-2015?id=378d360d-276f-442b-8147-932a8e4b75cf